Etiology and pathophysiology of fibromyalgia
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Published:
Sep 16, 2023
Keywords:
Pathological conditions, Fibromyalgia, Chronic pain, Autonomic nervous system
Main Article Content
Abstract
Fibromyalgia is a chronic condition of unknown etiology unrelated to specific laboratory markers for diagnosis because of poor etiopathogenesis. In general, the changes common to fibromyalgia are also seen in other chronic pain conditions, making the pathogenesis controversial among different pathological conditions. The unknown etiology makes the diagnosis difficult and consequently has repercussions on a not so effective treatment of patients with fibromyalgia. The restoration of systemic disorders provides a wide spectrum of therapeutic possibilities with the potential to guide professionals in establishing goals and evaluation methods. Therefore, this narrative review discusses the etiological and pathophysiological hypotheses involved in the development of fibromyalgia.
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1.
Almanza APMC, Cruz DS da, Oliveira-Júnior SA de, Martinez PF. Etiology and pathophysiology of fibromyalgia. Health Sci J [Internet]. 2023Sep.16 [cited 2024May9];13(3):3-. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1420
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NARRATIVE REVIEW
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3. Cabo-meseguer A, Cerdá-olmedo G, Trillo-mata L. Fibromialgia: prevalencia , perfiles epidemiológicos y costes económicos. 2017;149(10):441-8. https://doi.org/10.1016/j.medcli.2017.06.008
4. Souza JB, Perissinotti DMN. The prevalence of fibromyalgia in Brazil - a population-based study with secondary data of the study on chronic pain prevalence in Brazil. Brazilian J Pain. 2018;1(4):345-8. https://doi.org/10.5935/2595-0118.20180065
5. Maffei ME. Fibromyalgia: Recent advances in diagnosis, classification, pharmacotherapy and alternative remedies. Int J Mol Sci. 2020;21(21):7877. https://doi.org/10.3390/ijms21217877
6. Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int J Mol Sci. 2021;22(8):3891. https://doi.org/10.3390/ijms22083891
7. Briones-Vozmediano E, Vives-Cases C, Ronda-Pérez E, Gil-González D. Patients' and professionals' views on managing fibromyalgia. Pain Res Manag. 2013;18(1):19-24. https://doi.org/10.1155/2013/742510
8. Marques AP, Santo ASE, Berssaneti AA, Matsutani LA, Yuan SLK. A prevalência de fibromialgia: atualização da revisão de literatura. Rev Bras Reumatol. 2017;57(4):356-63. https://doi.org/10.1016/j.rbr.2016.10.004
9. Wolfe F, Walitt B, Perrot S, Rasker JJ, Häuser W. Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias. PLoS One. 2018;13(9):e0203755. https://doi.org/10.1371/journal.pone.0203755
10. Font Gayà T, Bordoy Ferrer C, Juan Mas A, Seoane-Mato D, Álvarez Reyes F, Delgado Sánchez M, et al; Working Group Proyecto EPISER2016. Prevalence of fibromyalgia and associated factors in Spain. Clin Exp Rheumatol. 2020;38 Suppl 123(1):47-52.
11. Heidari F, Afshari M, Moosazadeh M. Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol Int. 2017;37(9):1527-39. https://doi.org/10.1007/s00296-017-3725-2
12. Häuser W, Brähler E, Ablin J, Wolfe F. Modified 2016 American College of Rheumatology Fibromyalgia Criteria, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy, and the Prevalence of Fibromyalgia. Arthritis Care Res. 2021;73(5):617-25. https://doi.org/10.1002/acr.24202
13. Jones GT, Atzeni F, Beasley M, Macfarlane GJ, Group E, Building P. The prevalence of fibromyalgia in the general population - a comparison of the American College of Rheumatology 1990, 2010 and modified 2010 classification criteria. Arthritis Rheumatol. 2015;67(2):568-75. https://doi.org/10.1002/art.38905
14. Berger A, Sadosky A, Dukes EM, Edelsberg J, Zlateva G, Oster G. Patterns of healthcare utilization and cost in patients with newly diagnosed fibromyalgia. Am J Manag Care. 2010;16(5 Suppl):126-37.
15. Palacio A, Uribe CL, Li H, Hanna J, Deminski M, Alvir J, et al. Financial and clinical characteristics of fibromyalgia: a case-control comparison. Am J Manag Care. 2010;16(5 Suppl):118-25.
16. Berger A, Dukes E, Martin S, Edelsberg J, Oster G. Characteristics and healthcare costs of patients with fibromyalgia syndrome. Int J Clin Pract. 2007;61(9):1498-508. https://doi.org/10.1111/j.1742-1241.2007.01480.x
17. Walitt B, Katz RS, Bergman MJ, Wolfe F. Three-Quarters of Persons in the US Population Reporting a Clinical Diagnosis of Fibromyalgia Do Not Satisfy Fibromyalgia Criteria: The 2012 National Health Interview Survey. PLoS One. 2016;11(6):e0157235. https://doi.org/10.1371/journal.pone.0157235
18. Winkelmann A, Perrot S, Schaefer C, Ryan K, Chandran A, Sadosky A, Zlateva G. Impact of fibromyalgia severity on health economic costs: results from a European cross-sectional study. Appl Health Econ Health Policy. 2011;9(2):125-36. https://doi.org/10.2165/11535250-000000000-00000
19. Lacasse A, Bourgault P, Choinière M. Fibromyalgia-related costs and loss of productivity: a substantial societal burden. BMC Musculoskelet Disord. 2016;17:168. https://doi.org/10.1186/s12891-016-1027-6
20. Choy E, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, Kramer E. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res. 2010;10:102. https://doi.org/10.1186/1472-6963-10-102
21. Hackshaw K V., Aykas DP, Sigurdson GT, Plans M, Madiai F, Yu L, et al. Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders. J Biol Chem. 2019;294(7):2555-68. https://doi.org/10.1074/jbc.RA118.005816
22. Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain Kathleen. Neuroscience. 2016;338:114-29. https://doi.org/10.1016/j.neuroscience.2016.06.006
23. SchreibeR KL, Loggia ML, Kim J, Cahalan CM, NapadoW V, Edwards RR. Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe. J Pains. 2017;18(7):855-67. https://doi.org/10.1016/j.jpain.2017.02.437
24. Clauw DJ. Fibromyalgia and related conditions. Mayo Clin Proc. 2015;90(5):680-92. https://doi.org/10.1016/j.mayocp.2015.03.014
25. Albrecht DS, MacKie PJ, Kareken DA, Hutchins GD, Chumin EJ, Christian BT, Yoder KK. Differential dopamine function in fibromyalgia. Brain Imaging Behav. 2016;10(3):829-39. https://doi.org/10.1007/s11682-015-9459-4
26. Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC. Accelerated brain gray matter loss in fibromyalgia patients: Premature aging of the brain? J Neurosci. 2007;27(15):4004-7. https://doi.org/10.1523/JNEUROSCI.0098-07.2007
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