Relação entre Ácido Úrico Sérico e Capacidade Antioxidante em uma População de Hipertensos Atendidos em Unidade Básica de Saúde do Sul de Minas Gerais/ Relation between Serum Uric Acid and Antioxidant Capacity in a Population of Hypertensive Patients in a
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Abstract
Objetivo: Investigar a relação entre os níveis séricos de ácido úrico e capacidade antioxidante com a pressão arterial em indivíduos hipertensos. Métodos: Foram coletados sangue e amostras de urina isolada de 76 sujeitos (21-65 anos) provenientes de unidade básica de saúde. Antes da coleta a pressão arterial foi aferida e os sujeitos foram divididos em três grupos: normotensos (N); hipertensos controlados (HC) e hipertensos não-controlados (HNC). Foram determinadas as concentrações séricas de ácido úrico, ureia, creatinina e capacidade antioxidante. Proteínas totais e creatinina foram determinadas em urina isolada. Resultados: Os valores médios de ácido úrico foram significativamente elevados no grupo HC (mulheres = 5,64±1,2mg/dL; homens = 6,1±2,6mg/dL) comparados aos normotensos (mulheres = 4,1±1,1mg/dL; homens = 5,1±1,8mg/dL) e HNC (mulheres = 4,82±1,1mg/dL; homens = 5,8±1,8mg/dL), p<0,001. Os valores de capacidade antioxidante expressos em μmol equivalentes Trolox/L foram significativamente maiores nos indivíduos usuários de inibidores da enzima conversora de angiotensina - IECA (690,9 ± 205,9) em comparação aos normotensos (568,0 ± 163,0) e usuários de outras classes de anti-hipertensivos (645,1 ± 145,0), p<0,01. Conclusão: Embora neste estudo o ácido úrico esteja elevado nos hipertensos, sua ação antioxidante pode contribuir diretamente para a diminuição do estresse oxidativo.
Palavras Chave: hipertensão, hiperuricemia, capacidade antioxidante
Objective: To investigate the relation between serum uric acid concentration and antioxidant status with blood pressure levels (BP) in hypertensive individuals. Methods: Blood and urine samples from 76 ambulatory patients (21-65 years-old) were analyzed. Based on the history and blood pressure levels, patients were divided into three groups: normal blood pressure (n=36), controlled hypertension (n=18) and not controlled hypertension (n=22). We analyzed urea, creatinine and serum antioxidant capacity from blood samples and proteins and creatinine from urine samples. Results: Controlled hypertension group had significantly higher blood uric acid (male=6,1±2,6mg/dl; female=5,64±1,2mg/dl) than normal (male=5,1±1,8mg/dl; female=4,1±1,1mg/dl) and not controlled blood pressure group (male=5,8±1,8mg/dl; female=4,8±1,1mg/dl; p<0,001). There was no correlation between uric acid and blood pressure. The values of antioxidant activity expressed in μmol equivalent Trolox/L were significantly higher in individuals treated with angiotensin converting enzyme (ACE) inhibitors (690,9 ± 205,9) than normotensive (568,0 ± 163,0) and users of other antihypertensive drugs (645,1 ± 145,0), p<0,01. Conclusion: Although in this study the uric acid is high in the hypertensive patients, its antioxidant activity may contribute directly to the reduction of oxidative stress.
Keywords: hypertension, hyperuricemia, antioxidant status.
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