Avaliação do Uso do Lactobacillus reuteri em Pacientes Portadores da Síndrome de Supercrescimento Bacteriano Diagnosticados por Teste Respiratório / Evaluation of the Use of Lactobacillus reuteri in Patients with Bacterial Overgrowth Syndrome Diagnosed
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Abstract
Objetivo: Avaliar a ação de probiótico constituído pelo Lactobacillus reuteri em pacientes selecionados como portadores da síndrome do supercrescimento bacteriano do intestino delgado (SSCBID), através do teste respiratório da lactulose. Métodos: Foram incluídos 21 pacientes que apresentavam sintomas gastrointestinais inespecíficos, mas sugestivos de SSCBID. Foram selecionados através do questionário específico, para serem submetidos ao teste respiratório para lactulose. Os indivíduos com teste positivo foram convocados para iniciarem tratamento com probiótico composto por 100.000.000 UFC de Lactobacillus reuteri por quatro semanas e posterior reavaliação dos sintomas. Resultados: O resultado do teste respiratório foi positivo em 13 (61,90%) participantes (p=0,0391). A principal queixa foi a dor e/ou desconforto abdominal, com 46,15% (6/13) dos casos. A síndrome do intestino irritável representou o diagnóstico prévio de 30,77% (4/13) dos casos. 9 dos 13 pacientes tratados (69,23%) obtiveram melhora do quadro clínico inicial com o uso do probiótico. Conclusão: As evidências indicam que novos estudos devem ser realizados sobre os probióticos, para que sua aplicação clínica na síndrome do supercrescimento bacteriano seja definida. Neste estudo, o probiótico reduziu a sintomatologia abdominal em pacientes com SSCBID, com impacto na qualidade de vida destes indivíduos.
Palavras chave: supercrescimento bacteriano, teste respiratório, síndrome do intestino irritável, probióticos.
ABSTRACT
Objective: To assess the efficacy of probiotic Lactobacillus reuteri made by patients selected as having syndrome of small intestinal bacterial overgrowth (SSCBID) through the lactulose breath test. Methods: We included 21 patients who had nonspecific gastrointestinal symptoms, but suggestive of SSCBID, who were selected through specific questionnaire to be submitted to the breath test lactulose. Individuals with a positive test were called for starting treatment with probiotic composed of Lactobacillus reuteri UFC 100 million for four weeks and subsequent reassessment of symptoms. Results: The results of the breath test was positive in 13 (61.90%) participants (p=0.0391). The main complaint was pain and/or abdominal discomfort, with 46.15% (6/13) of cases. The irritable bowel syndrome represented the previous diagnosis of 30.77% (4/13) of cases. Nine out of the 13 patients (69.23%) had clinical improvement starting with the use of probiotics. Conclusion: Evidence indicates that further studies should be conducted on probiotics, so its clinical application in bacterial overgrowth syndrome is defined. In this study, the probiotic reduced abdominal symptoms in patients with SSCBID, with impact on the quality of life of these individuals.
Keywords: bacterial overgrowth, breath test, irritable bowel syndrome, probiotics.
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