Influência do Tratamento Crônico com L-arginina na Função Renal de Ratos Submetidos a um Modelo Experimental de Doença Renal Crônica/ Influence of Chronic Treatment with L-arginine on Renal Function in Rats Subjected to an Experimental Model of Chronic Ki
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Abstract
Objective: To investigate possible improvements in renal function in rats undergoing chronic renal failure treated with L-arginine. Methods: 28 rats were divided into 4 groups: Control L1- (N=7): treatment with distilled water; L2 - Moderate Uremia (N=7): supplementation with L-arginine (100 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side; L3 - Moderate Uremia (N=6): supplementation with L-arginine (200 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side; L4 - Moderate Uremia (N=8): supplementation with L-arginine (500 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side. Results: Continuous administration of arginine L produced no significant change in creatinine dosage, urea and total protein. In glycemia L2 and L2 albumin there were minor changes. In fluid intake there were specific changes on days 6 and 8, only between L2 and control groups. Analyzing food intake, there were only significant changes (p <0.05) spot, on 5, 7 and 9 between L2 and L1 compared with the control, respectively. Regarding the urinary debit, there were significant change (p <0.01) between L3 and control. Conclusion: It was observed that L-arginine supplementation has no effect on renal failure, does not produce improvements in urea, creatinine, total protein and urinary debit. However, it produces changes in blood glucose and albumin, finding a standard dose response in statistical analysis.
Keywords: L-arginine, Chronic Renal Failure, Renal Function.
Objetivo: Investigar possíveis melhorias na função renal de ratos submetidos à insuficiência renal crônica e tratados com L-arginina. Metodologia: Foram utilizados 28 ratos divididos em 4 grupos: L1 - Controle (N=7): tratamento com água destilada; L2 - Uremia Moderada (N=7): suplementação com L-arginina (100mg/ kg), com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral; L3 - Uremia Moderada (N=6): suplementação com L-arginina (200mg/kg) com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral; L4 - Uremia Moderada (N=8): suplementação com L-arginina (500mg/kg) com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral. Resultados: A administração contínua de L-arginina não produziu alterações significativas nas dosagens de creatinina, ureia e proteína total. Nas dosagens de glicemia L2 e albumina L2 houve pequenas alterações. Na ingesta hídrica foram encontradas alterações pontuais nos dias 6 e 8, apenas entre os grupos L2 e controle. Analisando a ingesta alimentar, houve apenas alterações significativas (p<0,05) pontuais, nos dias 5, 7 e 9 entre L2 e L1, quando comparados ao controle, respectivamente. Em relação ao debito urinário, existiu alteração significativa (p<0,01) entres L3 e controle. Conclusão: Foi observada que a suplementação de L-arginina não possui efeitos na insuficiência renal, não produz melhorias em ureia, creatinina, proteínas totais e debito urinário. Porém, produz alterações em glicemia e albumina, não encontrando um padrão dose resposta nas análises estatísticas.
Palavras-chave: L-arginina, Insuficiência Renal Crônica, Função Renal.
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