Intestinal Microbiota and Sclerosis Lateral Amyotrophic

Main Article Content

Mariana Dantas de Carvalho Vilar
https://orcid.org/0000-0002-9988-877X
Sancha Helena de Lima Vale
https://orcid.org/0000-0002-0972-1678
Eliane Lopes Rosado
https://orcid.org/0000-0003-0889-4662
Mário Emílio Teixeira Dourado Júnior
José Brandão-Neto
https://orcid.org/0000-0003-3414-5171
Lúcia Leite-Lais
https://orcid.org/0000-0002-8061-7048

Abstract

The human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotypes of many chronic and inflammatory diseases. This association is explained by the functions of the IM and the existing bi-directional communication of the microbiota-intestine-brain axis. Studies have uncovered new evidence between the IM and neurodegenerative diseases recently, including amyotrophic lateral sclerosis (ALS). Given this, the present narrative review discusses didactically about IM, its functions, its relationship with the neuroimmune-endocrine system, and its association with neurodegenerative diseases, with emphasis on ALS.



Article Details

How to Cite
1.
Vilar MD de C, Vale SH de L, Rosado EL, Dourado Júnior MET, Brandão-Neto J, Leite-Lais L. Intestinal Microbiota and Sclerosis Lateral Amyotrophic. HSJ [Internet]. 2022 Mar. 29 [cited 2024 Nov. 4];12(1):3-13. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1223
Section
NARRATIVE REVIEW
Author Biographies

Mariana Dantas de Carvalho Vilar, Federal University of Rio Grande do Norte (UFRN)

Nutritionist at the Federal University of Rio Grande do Norte (UFRN).

Sancha Helena de Lima Vale, Federal University of Rio Grande do Norte (UFRN)

Professor of Clinical Nutrition at UFRN, PhD in Health Sciences at UFRN.

Eliane Lopes Rosado, Josué de Castro Nutrition Institute (INJC), Federal University of Rio de Janeiro (UFRJ)

Professor of Clinical Nutrition at UFRJ, Master and Doctor in Food Science and Technology at the Federal University of Viçosa.

Mário Emílio Teixeira Dourado Júnior, Federal University of Rio Grande do Norte (UFRN)

Professor of Neurology at UFRN, Master in Biochemistry and Doctor in Health Sciences at UFRN.

José Brandão-Neto, Federal University of Rio Grande do Norte (UFRN)

Professor of Endocrinology at UFRN, Master and Doctor in Internal Medicine at the Faculty of Medicine of Ribeirão Preto, University of São Paulo.

Lúcia Leite-Lais, Federal University of Rio Grande do Norte (UFRN)

Professor of Clinical Nutrition at UFRN, PhD in Health Sciences at UFRN.

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