Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol

Main Article Content

Mário Flávio Cardoso de Lima
https://orcid.org/0000-0002-5735-4411
Marina Guedes Fraga Lopes
https://orcid.org/0000-0003-4035-8448
Wellington Henrique Justo Neto
https://orcid.org/0000-0002-3496-409X
Cláudio Teodoro de Souza
https://orcid.org/0000-0003-4904-5675

Abstract

Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.



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1.
Cardoso de Lima MF, Fraga Lopes MG, Justo Neto WH, de Souza CT. Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol. HSJ [Internet]. 2022 Dec. 12 [cited 2024 Nov. 2];12(4):28-34. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
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ORIGINAL ARTICLE
Author Biographies

Mário Flávio Cardoso de Lima, University Hospital of the Juiz de Fora Federal University

Nutritionist at the Empresa Brasileira de Serviços Hospitalares and University Hospital at the Federal University of Juiz de Fora. Doctoral student in Health at the Federal University of Juiz de Fora. Master in Nutrition Sciences at the Federal University of Viçosa, MG.

Marina Guedes Fraga Lopes, Juiz de Fora Federal University

Nutritionist, Doctoral Student in Health at the Juiz de Fora Federal University, Master in Health Sciences at the Federal University of Uberlândia.

Wellington Henrique Justo Neto, Juiz de Fora Federal University

Physical Educator, Master's Student in Health at the Juiz de Fora Federal University.

Cláudio Teodoro de Souza, Juiz de Fora Federal University

Full Professor at the Department of Internal Medicine at the Juiz de Fora Federal University, Doctor in Internal Medicine at the University of Campinas.

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