Drug-related female autointoxication registered at a toxicology care center

Main Article Content

Maria Beatriz de Sousa
https://orcid.org/0000-0003-4379-3162
Renata Sano Lini
https://orcid.org/0000-0002-6161-2225
Magda Lúcia Félix de Oliveira
https://orcid.org/0000-0003-4095-9382
Simone Aparecida Galerani Mossini
https://orcid.org/0000-0001-9535-0983

Abstract

Objective: To analyze the data on epidemiological records of autointoxication reports registered at a toxicological assistance center. Methods: Exploratory, descriptive, and retrospective study with the analysis of secondary data, conducted from the audit on Toxicological Occurrence Notification and Attendance forms, referring to the period from 2014 to 2018, filed in a toxicological information and assistance center, located in a municipality in southern Brazil. The data obtained were compiled in spreadsheets and analyzed using simple descriptive statistics. Results: 2,942 epidemiological records on women's autointoxication were audited, 72.0% of the total cases in the period studied. The predominant age group was 18 to 29 years old, with 1697 (57.7%) cases. The main toxic agent was medication, and the only agent of intoxication in 2,358 cases (80.1%). Psychotropic drugs accounted for 55.2% (1,593) of the cases, mainly antiepileptic and psychoanalytic drugs. Clonazepam was present in 567 (35.6%) suicide attempts and as the sole agent in 275 (17.3%) of them. In 873 cases (54.8%), mental illness was reported, in 546 (34.3%) previous suicide attempts, and 1,082 (67.9%) continued use of psychotropic medication. The main outcome was hospital discharge in 1,239 cases (77.8%). Conclusion: The study showed an increase in cases of female autointoxication over the period studied. The high percentage of autointoxication with psychotropic medications may be related to the ease of access at home and society's medicalization.



Article Details

How to Cite
1.
Sousa MB de, Lini RS, de Oliveira MLF, Mossini SAG. Drug-related female autointoxication registered at a toxicology care center. Health Sci J [Internet]. 2021Mar.9 [cited 2024Apr.27];11(1):14-1. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/993
Section
ORIGINAL ARTICLE
Author Biographies

Maria Beatriz de Sousa, State University of Maringá

Pharmacist and specialist in Urgency and Emergency with an emphasis on Pharmacy from the State University of Maringá, Maringá, PR, Brazil.

Renata Sano Lini, State University of Maringá

Pharmacist, specialist in Health Management and Master in Biosciences and Pathophysiology by the State University of Maringá, Maringá, PR, Brazil. Currently PhD student in the Biosciences and Pathophysiology program.

Magda Lúcia Félix de Oliveira, State University of Maringá

Nurse, PhD in Public Health from the State University of Campinas. She is currently a professor in the Postgraduate Program in Nursing at the State University of Maringá and coordinator of the Poison Control Center at the University Hospital of Maringá, PR, Brazil. She works in the area of Public Health and Public Health Nursing, with an emphasis on Studies on Poison Control and Drugs of Abuse.

Simone Aparecida Galerani Mossini, State University of Maringá

Pharmacist, PhD in Biological Sciences from the State University of Maringá, is currently a professor in the Post-Graduate Program in Biosciences and Pathophysiology at the State University of Maringá, Maringá, PR, Brazil. She works with undergraduate and graduate education, with experience in studies of Social Toxicology and Toxicological Analysis.

References

World Health Organization [Internet]. Preventing suicide: a global imperative. Geneva: World Health Organization; 2014 [cited 2020 Dec 16]. Avaible from: https://bit.ly/2Yrvns5
O'Neill S, Ferry F, Murphy S, Corry C, Bolton D, Devine B, et al. Patterns of suicidal ideation and behavior in northern ireland and associations with conflict related trauma. PLoS One. 2014;9(3):e91532. https://doi.org/10.1371/journal.pone.0091532 PMid:24646627 PMCid:PMC3960133
Storino BD, Campos CF, Chicata LCdO, Campos MdA, Matos MSdC, Nunes RMCM, et al. Atitudes de profissionais da saúde em relação ao comportamento suicida. Cad Saúde Colet. 2018;26(4):369-77. https://doi.org/10.1590/1414-462x201800040191
Turecki G, Brent DA. Suicide and suicidal behaviour. Lancet. 2016;387:1227-9. https://doi.org/10.1016/S0140-6736(15)00234-2
Dufort M, Sten MB, Gumpert CH. Physical domestic violence exposure is highly associated with suicidal attempts in both women and men. Results from the national public health survey in Sweden. Eur J Public Health. 2015;25(3):413-8. https://doi.org/10.1093/eurpub/cku198 PMid:25471557 PMCid:PMC4440449
Stevens D, Wilcox HC, MacKinnon DF, Mondimore FM, Schweizer B, Jancic D, et al. Posttraumatic Stress Disorder increases risk for suicide attempt in adults with recurrent major depression. Depress Anxiety. 2013;30(10):940-6. https://doi.org/10.1002/da.22160 PMid:23893768 PMCid:PMC4026925
Santos SA, Legay LF, Aguiar FP, Lovisi GM, Abelha L, Oliveira SP. Tentativas e suicídios por intoxicação exógena no Rio de Janeiro, Brasil: análise das informações através do linkage probabilístico. Cad Saúde Pública. 2014;30(5):1057-66. https://doi.org/10.1590/0102-311X00054213 PMid:24936821
World Health Organization [Internet]. Suicide in the world: Global Health Estimates. Geneva: World Health Organization; 2019. [cited 2020 Dec 16]. Avaible from: https://apps.who.int/iris/handle/10665/326948
Huang YC, Wu YW, Chen CK, Wang LJ. Methods of suicide predict the risks and method-switching of subsequent suicide attempts: a community cohort study in Taiwan. Neuropsychiatr Dis Treat. 2014;10:711-8 https://doi.org/10.2147/NDT.S61965 PMid:24833904 PMCid:PMC4015797
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Perfil epidemiológico das tentativas e óbitos por suicídio no Brasil e a rede de atenção à saúde. Boletim Epidemiológico. [Internet] 2017 [2020 dec 16];48(30). Avaiable from: https://bit.ly/3j01DvT
Lee J, Bang YS, Min S, Ahn JS, Kim H, Cha YS, et al. Characteristics of adolescents who visit the emergency department following suicide attempts: comparison study between adolescents and adults. BMC Psychiatry. 2019;19(231). https://doi.org/10.1186/s12888-019-2213-5 PMid:31349782 PMCid:PMC6660711
Borba LO, Ferreira ACZ, Capistrano FC, Kalinke LP, Maftum MA, Maftum GJ. Fatores associados à tentativa de suicídio por pessoas com transtorno mental. REME - Rev Min Enferm. 2020;24:e-1284. https://doi.org/10.5935/1415-2762.20200013
Bahia CA, Avanci JQ, Pinto LW, Minayo MCS. Lesão autoprovocada em todos os ciclos da vida: perfil das vítimas em serviços de urgência e emergência de capitais do Brasil. Cienc Saúde Coletiva. 2017;22(9):2841-50. https://doi.org/10.1590/1413-81232017229.12242017 PMid:28954135
Costa AO, Alonzo HGA. Brazilian Poison Control Centers: preliminary description of their organization and functions. Saúde Debate. 2019;43(120):110-21. https://doi.org/10.1590/0103-1104201912008
Aguiar KVCS, Cruz RC, Silva RTA, Bonfim AS. Intoxicação exógena acidental em crianças no estado da Bahia: 2013 a 2017. Rev Acervo Saúde. 2020;12(11):e3422. https://doi.org/10.25248/reas.e3422.2020
Cha ES, Chang SS, Gunnell D, Eddleston M, Khang YH, Lee W J. Impact of paraquat regulation on suicide in South Korea. Int J Epidemiol. 2016;45(2):470-9. https://doi.org/10.1093/ije/dyv304 PMid:26582846
Han B, Kott PS, Hughes A, Mckeon R, Blanco C, Compton WM. Estimating the rates of deaths by suicide among adults who attempt suicide in the United States. J Psychiatr Res. 2016;77:125-133. https://doi.org/10.1016/j.jpsychires.2016.03.002 PMid:27032110
Domingues PHF, Galvão TF, Andrade KRCd, Sá PTTd, Silva MT, Pereira MG. Prevalência da automedicação na população adulta do Brasil: revisão sistemática. Rev Saúde Pública. 2015;49:36. https://doi.org/10.1590/S0034-8910.2015049005709
World Health Organization [Internet]. Collaborating Centre for Drug Statistics Methodology. Oslo: World Health Organization; 2015. [cited 2020 Dec 16]. Avaible from: http://www.whocc.no/atcddd/
Félix TA, Oliveira EN, de Oliveira Lopes MV, Parente JRF, de Araújo Dias MS, Moreira RMM. Fatores de risco para tentativa de suicídio: produção de conhecimento no Brasil. Rev Contexto Saúde. 2016;16(31):173-85. https://doi.org/10.21527/2176-7114.2016.31.173-185
Santos AS, Legay LF, Lovisi GM. Substâncias tóxicas e tentativas e suicídios: considerações sobre acesso e medidas restritivas. Cad Saúde Colet. 2013;21(1):53-61. https://doi.org/10.1590/S1414-462X2013000100009
Oliveira SM, Ribeiro TLS, Alves JMF, Lima JP, Morais ICO. Tentativas de suicídio por uso de substância tóxicas: Análise em um centro de informações e assistência toxicológica. Rev Cereus. 2020;12(3):175-85. https://doi.org/10.18605/2175-7275/cereus.v12n3p175-185
Grigoletto AP, Souto VT, Terra MG, Tisott ZL, Ferreira CN. Suicide attempts notified in a teaching hospital in the state of Rio Grande do Sul, 2014-2016. Rev Fun Care Online. 2020; 12:413-9. https://doi.org/10.9789/2175-5361.rpcfo.v12.8349
Moreira RMM, Félix TA, Flôr SMC, Oliveira EN, Albuquerque JHM. Análise epidemiológica dos óbitos por suicídio. Sanare [Internet]. 2017 [cited 2021 Jan 30];16(Suppl 1):29-34. Avaiable from: https://sanare.emnuvens.com.br/sanare/article/view/1136
Pires MCC, Raposo MCF, Sougey EB, Bastos-Filho OC, Silva TS, Passos MP. Indicadores de risco para tentativa de suicídio por envenenamento: um estudo caso-controle. J Bras Psiquiatr. 2015;64(3):193-9. https://doi.org/10.1590/0047-2085000000078
Moreira LCO, Bastos PRHO. Prevalência e fatores associados à ideação suicida na adolescência: revisão de literatura. Revista Quadrimestral da Associação Brasileira de Psicologia Escolar e Educacional. 2015;19(3):445-453.https://doi.org/10.1590/2175-3539/2015/0193857
Vidal CEL, Gontijo ECDM, Lima LA. Tentativas de suicídio: fatores prognósticos e estimativa do excesso de mortalidade. Cad Saúde Publica. 2013;29(1):175-87. https://doi.org/10.1590/S0102-311X2013000100020 PMid:23370037
Turhan E, Inandi T, Aslan M, Zeren C. Epidemiology of attempted suicide in Hatay, Turkey. Neurosciences (Riyadh). 2011;16(4):347-52. PMID: 21983378
Oliveria EN, Félix TA, Mendonça CBL, Ferreira GB, Freire MA, Lima PSF, et al. Tentativa de suicídio por intoxicação exógena: contexto de notificações compulsórias. Rev G&S. 2015;6(3):2497-511. Avaiable from: https://periodicos.unb.br/index.php/rgs/article/view/3125
Portugal. Ministério da Saúde. Direção-Geral da Saúde (DGS). Programa Nacional para a Saúde Mental: Plano Nacional de Prevenção do Suicídio 2013/2017 [Internet]. 2013 [cited 2021 Jan 30]. Avaiable from: https://repositorio.observatoriodocuidado.org/handle/handle/2519
Moreira DL, Martins MC, Gubert FA, Souza FSP. Perfil de pacientes atendidos por tentativa de suicídio em um centro de assistência toxicológica. Cienc Enferm. 2015;21(2):63-75. https://doi.org/10.4067/S0717-95532015000200007
Vieira LP, Santana VTP, Suchara EA. Caracterização de tentativas de suicídios por substâncias exógenas. Cad Saúde Colet. 2015;23(2):118-23. https://doi.org/10.1590/1414-462X201500010074
Nasario M, Silva MM. O consumo excessivo de medicamentos psicotrópicos na atualidade. Artigo científico-Pós-Graduação de Saúde Mental e Atenção Psicossocial no Centro Universitário para o Desenvolvimento do Alto Vale do Itajaí. 2014. Avaiable from: https://bit.ly/3pARtnJ
Orlandi P, Noto AR. Uso indevido de benzodiazepínicos: um estudo com informantes-chave no município de São Paulo. Rev Latino-Am Enfermagem. 2005;13:896-902. https://doi.org/10.1590/S0104-11692005000700018 PMid:16400457
Toscano MM, Landim JTA, Rocha AB, Sousa-Muñoz RL. Intoxicações exógenas agudas registradas em centro de assistência toxicológica. Rev Saúde Pesq. 2016;9(3):425-32. https://doi.org/10.17765/1983-1870.2016v9n3p425-432
Trevisan EPT, Santos JAT, Oliveira MLFd. Suicide attempts in women: data from a toxicological assistance center in Parana. Rev Min Enferm. 2013;17(2):412-7. https://doi.org/10.5935/1415-2762.20130031
Wieczorkievicz AM, Mazon LM, Raissa CM, Maia EW, Siebeneichler JL. Caracterização das tentativas de suicídio atendidas em pronto atendimento geral. Saúde Rev [Internet]. 2016 [cited 2021 Jan 30];16(43):53-62. Avaiable from: http://bit.ly/2L89ivA