Probióticos na redução de sintomas de ansiedade e depressão: uma revisão integrativa
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Objetivos: sumarizar estudos que avaliaram a suplementação de probióticos como estratégia terapêutica nos sintomas da ansiedade e depressão. Métodos: revisão integrativa de artigos indexados na base de dados PubMed, SciELO e Biblioteca Virtual em Saúde publicados de janeiro de 2010 a setembro de 2019. Para isso, utilizou-se a conjugação dos descritores: “intestino”, “cérebro”, “microbiota intestinal”, “ansiedade”, “depressão”, “probióticos”, nos idiomas português e inglês. Resultados: Após a aplicação dos critérios de inclusão e exclusão, 13 ensaios clínicos randomizados foram selecionados. O tempo de duração dos estudos, em sua maioria, foi de 8 ou 12 semanas (61,5%; n = 8), e a forma mais ofertada do suplemento foi o probiótico em pó (46,2%; n = 6) e em cápsula (30,8%; n = 4). Sobre a utilização de escalas como parâmetro de avaliação dos sintomas de ansiedade e depressão, 38,5% (n = 5) utilizaram apenas uma escala e 69,2% (n = 8) utilizaram a combinação de duas ou três escalas. Em relação ao gênero das bactérias, a maior parte dos estudos utilizou Lactobacillus e Bifidobacterium em conjunto (53,8%; n = 7). Apesar das limitações metodológicas e dos resultados inconsistentes, a maioria dos ensaios clínicos (76,9%; n = 10) evidenciaram uma redução significativa dos sintomas relacionados à ansiedade e depressão através da suplementação de probióticos. Conclusão: As evidências indicam que a suplementação com probióticos apresenta potencial promissor na redução dos sintomas de ansiedade e depressão, no entanto são necessárias pesquisas adicionais sobre essa estratégia como terapia adjuvante no tratamento efetivo para a saúde mental.
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