Estudo duplo-cego, unicêntrico, randomizado, avaliando a eficácia o mononitrato de isossorbida na prevenção da oclusão de artéria radial comparado ao placebo em pacientes submetidos a procedimento coronariano percutâneo eletivo: protocolo de estudo
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Conteúdo do artigo principal
Resumo
Objetivos: O objetivo primário deste estudo será avaliar a eficácia do mononitrato de isossorbida subcutâneo e peri-arterial na prevenção da oclusão da artéria radial (OAR) após procedimento coronariano percutâneo (PCP) realizado pela via transradial (VTR). Como objetivos secundários, definir a incidência de OAR em no serviço assim como avaliar variáveis relacionadas ao risco de oclusão.Métodos: Estudo unicêntrico, duplo-cego, randomizado, onde serão incluídos pacientes internados e eletivos de hospital de alta complexidade, que derem entrada para a realização de PCP, diagnóstico ou terapêutico, por VTR, em quadros coronarianos estáveis (eletivos) ou em síndromes coronarianas agudas. A amostra será dividida de forma randômica em grupo que receberá a medicação e um grupo controle. Todos os participantes serão submetidos a avaliação palpatória da patência da artéria radial e pelo teste inverso de Barbeau nas 24 horas e sete dias após o procedimento. Este será o primeiro estudo a avaliar o mononitrato de isossorbida como método farmacológico acessível e barato para prevenção da OAR após PCP por VTR.
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