Immunotherapeutic perspectives for COVID-19

Main Article Content

Lucas Gomes de Hollanda Cavalcanti
https://orcid.org/0000-0001-9713-1274
Luciana Xavier Oliveira
https://orcid.org/0000-0002-7983-4635
Melina Pezzo Bustamante
https://orcid.org/0000-0003-3502-6991
Marileia Chaves Andrade
https://orcid.org/0000-0002-4496-7331

Abstract

With the appearance of COVID-19, constant research on SARS-CoV-2 infection and its therapeutic prospects have begun. With an evident contribution of immunological activity to the pathogenesis of COVID-19, we highlight the main immunotherapeutic perspectives under its development. The involvement of neutrophilia and the formation of NETs (Neutrophil Extracellular Traps) is still being investigated as the clinical situation is worsening. One way to mitigate disease’s severity is by controlling neutrophil activity and the formation of NETs. Another way is to administer convalescent plasma or intravenous immunoglobulin (IgG) that can neutralize the entry of the virus into cells and modulate the immune response. However, the treatments are not yet definitive and lack favorable results.



Article Details

How to Cite
1.
Cavalcanti LG de H, Oliveira LX, Bustamante MP, Andrade MC. Immunotherapeutic perspectives for COVID-19. HSJ [Internet]. 2020 Nov. 26 [cited 2024 Nov. 2];10(4):6-9. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1002
Section
NARRATIVE REVIEW
Author Biographies

Lucas Gomes de Hollanda Cavalcanti, Faculty of Medicine of Itajubá (FMIt)

Academic of the 5th. year of the Faculty of Medicine of Itajubá (FMIT). Itajubá, MG, Brazil.

Luciana Xavier Oliveira, Faculty of Medicine of Itajubá (FMIt)

Academic of the 5th. year of the Faculty of Medicine of Itajubá (FMIT). Itajubá, MG, Brazil.

Melina Pezzo Bustamante, Faculty of Medicine of Itajubá (FMIt)

Academic of the 5th. year of the Faculty of Medicine of Itajubá (FMIT). Itajubá, MG, Brazil.

Marileia Chaves Andrade, Faculty of Medicine of Itajubá (FMIt)

Master and PhD in Immunology from the Federal University of Minas Gerais (UFMG). Post-doctorate by the  René Rachou Research Center - FIOCRUZ/MG. Professor at the State University of Montes Claros-UNIMONTES. Full Professor of the Discipline of Immunology, Microbiology and Parasitology, Faculty of Medicine of Itajubá (FMIt), Itajubá, MG, Brazil.

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