The Role of Innate Immunity in COVID-19

Main Article Content

Luiz Henrique Silva de Sordi
https://orcid.org/0000-0003-3349-6025
Isabela Sales Oliveira Magalhães
https://orcid.org/0000-0001-5200-0414
Daniela Abreu Casselhas
Mariléia Chaves Andrade
https://orcid.org/0000-0002-4496-7331

Abstract

The immune system plays an essential role in the COVID-19 pandemic, as it is involved in the pathogenesis and worsening of the disease. The purpose of this review is to address aspects of innate immunity in COVID-19, especially the role of neutrophils. The innate immune system corresponds to the organism's first defense, but a balance must be effective against the invader without harming the host excessively. An immune imbalance is related to more severe conditions and aberrant neutrophil activation, with lymphopenia and neutrophilia being predictors of a worse prognosis in patients with COVID-19. Neutrophilia is speculated to be an important source for the excessive formation of NET (Neutrophil Extracellular Traps), leading to increased inflammatory response and unfavorable evolution of the disease. NETs are also associated with the cytokine storm, another mechanism related to COVID-19's gravity. Therefore, strategies involving immunomodulation may have an essential role in controlling the disease.



Article Details

How to Cite
1.
Silva de Sordi LH, Magalhães ISO, Casselhas DA, Andrade MC. The Role of Innate Immunity in COVID-19 . HSJ [Internet]. 2020 Jul. 2 [cited 2024 Nov. 22];10(3):5-8. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997
Section
NARRATIVE REVIEW
Author Biographies

Luiz Henrique Silva de Sordi, Faculdade de Medicina de Itajubá

Acadêmico do 5° ano de Medicina da Faculdade de Medicina de Itajubá, Itajubá, MG, Brasil.

Isabela Sales Oliveira Magalhães, Faculdade de Medicina de Itajubá

Acadêmica do 5° ano de Medicina da Faculdade de Medicina de Itajubá, Itajubá, MG, Brasil; Graduação em Direito pelo Centro Universitário de Lavras, MG, Brasil.

Daniela Abreu Casselhas, Faculdade de Medicina de Itajubá

Acadêmica do 5° ano de Medicina da Faculdade de Medicina de Itajubá, Itajubá, MG, Brasil.

Mariléia Chaves Andrade, Faculdade de Medicina de Itajubá

Professora da Universidade Estadual de Montes Claros, Montes Claros, MG, Brasil; Pós-doutorado pela Universidade de Santiago de Compostela, USC, Espanha.

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