The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19

Main Article Content

Samira Costa Sampaio
https://orcid.org/0000-0002-3449-7401
Gabriel Santos Sacramento
https://orcid.org/0000-0002-9201-1545
Jessica Bomfim de Almeida
https://orcid.org/0000-0002-8016-734X

Abstract

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) emerged in China exponentially and is recognized as a multisystem disease that gradually elevates markers associated with iron metabolism as the infection becomes more intense, becoming a critical factor in the investigation of prognosis. We review the latest scientific findings on the behavior of iron and ferritin in pathophysiology and as laboratory markers in COVID-19 (Coronavirus Disease 2019).The findings showed that iron and ferritin play a key role in the pathogenesis of COVID-19, contributing to the worsening of the disease. Therefore, iron dysmetabolism, marked by hyperferritinemia, is associated with inflammatory states in SARS-CoV-2 infection, and ferritin measurement has been shown to be a useful laboratory marker with a clinical and discriminatory potential to define the severity and mortality during COVID-19.



Article Details

How to Cite
1.
Sampaio SC, Sacramento GS, de Almeida JB. The role of iron and ferritin in pathophysiology and as a laboratory marker in COVID-19. HSJ [Internet]. 2022 Aug. 29 [cited 2024 Nov. 2];12(3):12-21. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1275
Section
NARRATIVE REVIEW
Author Biographies

Samira Costa Sampaio, Federal University of Bahia

Academic of the 10th semester of Pharmacy at the Federal University of Bahia, Campus Anísio Teixeira.

Gabriel Santos Sacramento, Federal University of Bahia

Academic of the 6th semester of Pharmacy at the Federal University of Bahia, Campus Anísio Teixeira.

Jessica Bomfim de Almeida, Federal University of Bahia

PhD in Biology and Biotechnology of Microorganisms at the State University of Santa Cruz de Ilhéus - Bahia, Adjunct Professor of Pharmacy at the Federal University of Bahia, Campus Anísio Teixeira.

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