Circulation pattern of influenza A/B virus and Respiratory Syncytial Virus (RSV) in Fortaleza, Ceará, after the SARS-CoV-2 pandemic

Main Article Content

Jean Breno da Silva Silveira
https://orcid.org/0000-0002-0838-3195
Sarah Sousa Nascimento dos Santos
https://orcid.org/0000-0001-9749-2053
Lia Felipe de Araujo
Luís Carlos Mendes Cavalcante
Fabiane Feitosa de Medeiros Batista
https://orcid.org/0000-0003-2921-4929
Dinizia Mineia Ferreira Alves Diniz Martins
Alexandre de Almeida Monteiro
Caroline Aquino Moreira-Nunes
https://orcid.org/0000-0001-5845-3481

Abstract

Objective: To investigate the circulation patterns of respiratory viruses from January 2023 to May 2024 and to describe their epidemiological characteristics in the city of Fortaleza based on data obtained by molecular tests based on real-time PCR (qPCR).


Method: This retrospective epidemiological study was conducted to investigate patterns of infection by influenza A/B virus, Respiratory Syncytial Virus (RSV), and SARS-CoV-2, and the prevalence and incidence of these respiratory viruses in the city of Fortaleza from January 2023 to May 2024.


Result: There was a significant difference in the distribution of total positive cases and the demand for molecular tests between the periods analyzed (p<0.05). A significant difference was also observed between the total number of infections caused by SARS-CoV-2 and infections caused by Influenza (p=0.0041) and RSV (p=0.0012) in the same period. No significant differences were observed between influenza and RSV during the study period. The monthly infection rates revealed a seasonal trend in the incidence of infections caused by influenza and RSV.


Conclusion: The proportion of SARS-CoV-2 detection in relation to the number of positive results showed a considerable decline in the first half of 2024, with an increase in the number of infections caused by influenza virus and RSV. In this way, we evidenced a change in the pattern of viral circulation of the three respiratory viruses, revealing the reestablishment of the seasonality and incidence of influenza A/B virus and RSV for the first time after the COVID-19 pandemic.



Article Details

How to Cite
1.
Jean Breno da Silva Silveira, Sarah Sousa Nascimento dos Santos, Lia Felipe de Araujo, Luís Carlos Mendes Cavalcante, Fabiane Feitosa de Medeiros Batista, Dinizia Mineia Ferreira Alves Diniz Martins, et al. Circulation pattern of influenza A/B virus and Respiratory Syncytial Virus (RSV) in Fortaleza, Ceará, after the SARS-CoV-2 pandemic. HSJ [Internet]. 2025 Feb. 28 [cited 2025 Mar. 8];15:e1569. Available from: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1569
Section
ORIGINAL ARTICLE

References

Chow EJ, Uyeki TM, Chu HY. The effects of the COVID-19 pandemic on community respiratory virus activity. Nat Rev Microbiol. 2022;21(3):195-210. http://doi.org/10.1038/s41579- 022-00807-9. PMid:36253478.

Olsen SJ, Winn AK, Budd AP, et al. Changes in influenza and other respiratory virus activity during the COVID-19 pandemic – United States, 2020-2021. MMWR Morb Mortal Wkly Rep. 2021;70(29):1013-9. http://doi.org/10.15585/mmwr.mm7029a1. PMid:34292924. DOI: https://doi.org/10.15585/mmwr.mm7029a1

Sullivan SG, Carlson S, Cheng AC, et al. Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020. Euro Surveill. 2020;25(47):2001847. http://doi. org/10.2807/1560-7917.ES.2020.25.47.2001847. PMid:33243355. DOI: https://doi.org/10.2807/1560-7917.ES.2020.25.47.2001847

García-García E, Rodríguez-Pérez M, Melón García S, et al. Change on the circulation of respiratory viruses and pediatric healthcare utilization during the COVID-19 pandemic in Asturias, Northern Spain. Children. 2022;9(10):1464. http:// doi.org/10.3390/children9101464. PMid:36291400. DOI: https://doi.org/10.3390/children9101464

Iuliano AD, Roguski KM, Chang HH, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391(10127):1285-300. http:// doi.org/10.1016/S0140-6736(17)33293-2. PMid:29248255.

WHO: World Health Organization. Respiratory Syncytial Virus (RSV) disease [Internet]. Geneva: WHO; 2024 [cited 2024 Jun 24]. Available from: https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/ vaccine-standardization/respiratory-syncytial-virus-disease

Correa RA, Arancibia F, De Ávila Kfouri R, et al. Understanding the burden of respiratory syncytial virus in older adults in Latin America: an expert perspective on knowledge gaps. Pulm Ther. 2024;10(1):1-20. http://doi.org/10.1007/s41030-024-00253-3. PMid:38358618. DOI: https://doi.org/10.1007/s41030-024-00253-3

Murray CJL, Piot P. The potential future of the COVID-19 pandemic: will SARS-CoV-2 become a recurrent seasonal infection? JAMA. 2021;325(13):1249-50. http://doi.org/10.1001/ jama.2021.2828. PMid:33656519. DOI: https://doi.org/10.1001/jama.2021.2828

Kubale JT, Frutos AM, Balmaseda A, et al. High co-circulation of influenza and severe acute respiratory syndrome coronavirus 2. Open Forum Infect Dis. 2022;9(12):c642. http://doi.org/10.1093/ ofid/ofac642. PMid:36519125. DOI: https://doi.org/10.1093/ofid/ofac642

Cowling BJ, Ali ST, Ng TWY, et al. Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study. Lancet Public Health. 2020;5(5):e279-88. http://doi.org/10.1016/ S2468-2667(20)30090-6. PMid:32311320. DOI: https://doi.org/10.1016/S2468-2667(20)30090-6

WHO: World Health Organization. COVID-19 disease in children and adolescents: scientific brief [Internet]. Geneva: WHO; 29 sept. 2021 [cited 2024 Jun 24]. Available from: https://www. who.int/publications/i/item/WHO-2019-nCoV-Sci_Brief- Children_and_adolescents-2021.1

Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545-55. http://doi.org/10.1016/ S0140-6736(10)60206-1. PMid:20399493. DOI: https://doi.org/10.1016/S0140-6736(10)60206-1

Bardsley M, Morbey RA, Hughes HE, et al. Epidemiology of respiratory syncytial virus in children younger than 5 years in England during the COVID-19 pandemic, measured by laboratory, clinical, and syndromic surveillance: a retrospective observational study. Lancet Infect Dis. 2023;23(1):56-66. http:// doi.org/10.1016/S1473-3099(22)00525-4. PMid:36063828. DOI: https://doi.org/10.1016/S1473-3099(22)00525-4

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. http://doi.org/10.1016/S0140- 6736(20)30211-7. PMid:32007143. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7

Samulowitz A, Gremyr I, Eriksson E, Hensing G. “Brave men” and “emotional women”: a theory-guided literature review on gender bias in health care and gendered norms towards patients with chronic Pain. Pain Res Manag. 2018;2018(1):6358624. http://doi.org/10.1155/2018/6358624. PMid:29682130. DOI: https://doi.org/10.1155/2018/6358624

Brasil. Ministério da Saúde. Guia de vigilância epidemiológica: emergência de saúde pública de importância nacional pela Doença pelo coronavírus 2019 – COVID-19 [Internet]. Brasília; 2021 [cited 2024 Jun 24]. Available from: https://www.conasems. org.br/wp-content/uploads/2021/03/Guia-de-vigila%CC%82ncia-epidemiolo%CC%81gica-da-covid_19_15.03_2021.pdf

Freitas FTM. Sentinel surveillance of influenza and other respiratory viruses, Brazil, 2000-2010. Braz J Infect Dis. 2013;17(1):62-8. http://doi.org/10.1016/j.bjid.2012.09.001. PMid:23287541. DOI: https://doi.org/10.1016/j.bjid.2012.09.001

Brasil. Ministério da Saúde. Coronavírus Brasil [Internet]. Brasília; 2024 [cited 2024 Jun 24]. Available from: https://covid.saude. gov.br/

Moura FEA, Perdigão ACB, Siqueira MM. Seasonality of influenza in the tropics: a distinct pattern in northeastern Brazil. Am J Trop Med Hyg. 2009;81(1):180-3. http://doi.org/10.4269/ ajtmh.2009.81.180. PMid:19556586. DOI: https://doi.org/10.4269/ajtmh.2009.81.180

Gamba-Sanchez N, Rodriguez-Martinez CE, Sossa-Briceño MP. Epidemic activity of respiratory syncytial virus is related to temperature and rainfall in equatorial tropical countries. Epidemiol Infect. 2016;144(10):2057-63. http://doi.org/10.1017/ S0950268816000273. PMid:26888544. DOI: https://doi.org/10.1017/S0950268816000273

Ceará. Governo do Estado. COVID-19: semana epidemiológica 47. Informe operacional [Internet]. Fortaleza: Secretário da Saúde do Ceará; 2023 [cited 2024 Jun 24]. Available from: https:// www.saude.ce.gov.br/wp-content/uploads/sites/9/2020/02/ Informe-covid-19-2023-SE-47.pdf

Ceará. Governo do Estado. Vigilância genômica do SARS-CoV-2 no Ceará: rastreio e monitoramento da circulação de variantes de preocupação. Nota técnica [Internet]. Fortaleza: Secretário da Saúde do Ceará; 2023 [cited 2024 Jul 3]. Available from: https:// www.saude.ce.gov.br/wp-content/uploads/sites/9/2020/02/ Nota_Tecnica_SEVIG_NOV_2023-2-1.pdf

Ceará. Governo do Estado. Cenário epidemiológico dos vírus respiratórios Informe operacional [Internet]. Fortaleza: Secretário da Saúde do Ceará; 2024 [cited 2024 Jul 3]. Available from: https://www.saude.ce.gov.br/wp-content/ uploads/sites/9/2018/06/INFORME-No1-PUBLICADO-Cenario-epidemiologico-dos-virus-respiratorios-2024.pdf

Habbous S, Hota S, Allen VG, Henry M, Hellsten E. Changes in hospitalizations and emergency department respiratory viral diagnosis trends before and during the COVID-19 pandemic in Ontario, Canada. PLoS One. 2023;18(6):e0287395. http://doi. org/10.1371/journal.pone.0287395. PMid:37327212. DOI: https://doi.org/10.1371/journal.pone.0287395

Ullrich A, Schranz M, Rexroth U, et al. Impact of the COVID-19 pandemic and associated non-pharmaceutical interventions on other notifiable infectious diseases in Germany: an analysis of national surveillance data during week 1–2016 – week 32–2020. Lancet Reg Health Eur. 2021;6:100103. http://doi. org/10.1016/j.lanepe.2021.100103. PMid:34557831. DOI: https://doi.org/10.1016/j.lanepe.2021.100103

Nasrullah A, Gangu K, Garg I, et al. Trends in hospitalization and mortality for influenza and other respiratory viruses during the COVID-19 pandemic in the United States. Vaccines. 2023;11(2):412. http://doi.org/10.3390/vaccines11020412. PMid:36851289. DOI: https://doi.org/10.3390/vaccines11020412

Wan L, Li L, Zhang H, et al. The changing pattern of common respiratory viruses among children from 2018 to 2021 in Wuhan, China. Arch Virol. 2023;168(12):291. http://doi.org/10.1007/ s00705-023-05891-7. PMid:37962775. DOI: https://doi.org/10.1007/s00705-023-05891-7

Sabadini JP. InfoGripe: VSR supera Covid-19 em óbitos de crianças pequenas [Internet]. Rio de Janeiro: FIOCRUZ; 2024 [cited 2024 Jul 3]. Available from: https://portal.fiocruz.br/ noticia/2024/04/infogripe-vsr-supera-covid-19-em-obitos-de-criancas-pequenas

Brasil. Ministério da Saúde. Protocolo de uso: Palivizumabe para prevenção da infecção pelo vírus sincicial respiratório [Internet]. Brasília; 2018 [cited 2024 Jun 24]. Available from: https://www.gov.br/conitec/pt-br/midias/relatorios/2018/ relatorio_protocolouso__palivizumabe.pdf

Most read articles by the same author(s)