Associação entre os transcritos do gene BCR-ABL e o perfil hematológico laboratorial

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Publicado: Set 6, 2022
DOI: https://doi.org/10.21876/rcshci.v12i3.1281
Palavras-chave:
Leucemia Mieloide Crônica, gene BCR ABL, Hematologia

Conteúdo do artigo principal

Marcelo Braga de Oliveira
Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)
https://orcid.org/0000-0002-5114-6099
Carolina de Alcântara Maneschy
Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)
https://orcid.org/0000-0002-1384-9180
Jairo Augusto Américo de Castro
Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)
https://orcid.org/0000-0002-2522-5041
Katarine Antonia dos Santos Barile
Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)
https://orcid.org/0000-0002-2229-6186
Maurício Koury Palmeira
Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)
Carlos Eduardo de Melo Amaral
Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

Resumo

Objetivo: Neste estudo, descrevemos os parâmetros hematológicos associados com os transcritos do gene BCR-ABL em pacientes com leucemia mieloide crônica (LMC). Métodos: Revisamos os resultados de 100 pacientes detectáveis para um dos transcritos do geneBCR-ABL. Os critérios de elegibilidade foram baseados na presença de um dos transcritos leucêmicos (b2a2, b3a2 e b2a2/b3a2), dados epidemiológicos e hematológicos completos. Os dados foram obtidos do sistema informatizado LABMASTER. O teste Kruskal-Wallis foi utilizado para comparar as medianas, das variáveis quantitativas, entre os transcritos do gene BCR-ABL e o teste qui-quadrado para comparar as variáveis qualitativas, adotando-se o p-valor com nível de significância menor ou igual a 0,05.Resultados: Quarenta e cinco pacientes (45%) apresentaram o transcrito b2a2, 24 (24%) o transcrito b3a2 e 31 (31%) uma coexpressão de b2a2/b3a2. Os indivíduos que expressaram o transcrito b3a2 apresentaram maior contagem de leucócitos e níveis de plaquetas, porém não encontramos diferenças, quando comparados com indivíduos que expressaram o outro transcrito. Conclusão: Concluímos que os transcritos do gene BCR-ABL não têm influência sobre os parâmetros hematológicos de pacientes com LMC nesse estudo.

Detalhes do artigo

Como Citar
1.
Oliveira MB de, Maneschy C de A, Castro JAA de, Barile KA dos S, Palmeira MK, Amaral CE de M. Associação entre os transcritos do gene BCR-ABL e o perfil hematológico laboratorial. Health Sci J [Internet]. 6º de setembro de 2022 [citado 11º de maio de 2024];12(3):61-6. Disponível em: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1281
Edição
v. 12 n. 3 (2022): Julho a Setembro de 2022
Seção
ARTIGO ORIGINAL
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Biografia do Autor

Marcelo Braga de Oliveira, Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

Master's student in Oncology and Medical Sciences at the Federal University of Pará.

Carolina de Alcântara Maneschy, Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

Biomedical graduate from the Metropolitan University Center of the Amazon

Jairo Augusto Américo de Castro, Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

Master in Virology from Instituto Evandro Chagas.

Katarine Antonia dos Santos Barile, Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

PhD in Biology of Infectious and Parasitic Agents from the Federal University of Pará.

Maurício Koury Palmeira, Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

Master in Biology of Infectious and Parasitic Agents from the Federal University of Pará.

Carlos Eduardo de Melo Amaral, Metropolitan University Center of the Amazon (UNIFAMAZ), Foundation Center for Hematology and Hemotherapy of the State of Pará (HEMOPA)

PhD in Genetics and Molecular Biology from the Federal University of Pará.

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