Associação entre os transcritos do gene BCR-ABL e o perfil hematológico laboratorial
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Resumo
Objetivo: Neste estudo, descrevemos os parâmetros hematológicos associados com os transcritos do gene BCR-ABL em pacientes com leucemia mieloide crônica (LMC). Métodos: Revisamos os resultados de 100 pacientes detectáveis para um dos transcritos do geneBCR-ABL. Os critérios de elegibilidade foram baseados na presença de um dos transcritos leucêmicos (b2a2, b3a2 e b2a2/b3a2), dados epidemiológicos e hematológicos completos. Os dados foram obtidos do sistema informatizado LABMASTER. O teste Kruskal-Wallis foi utilizado para comparar as medianas, das variáveis quantitativas, entre os transcritos do gene BCR-ABL e o teste qui-quadrado para comparar as variáveis qualitativas, adotando-se o p-valor com nível de significância menor ou igual a 0,05.Resultados: Quarenta e cinco pacientes (45%) apresentaram o transcrito b2a2, 24 (24%) o transcrito b3a2 e 31 (31%) uma coexpressão de b2a2/b3a2. Os indivíduos que expressaram o transcrito b3a2 apresentaram maior contagem de leucócitos e níveis de plaquetas, porém não encontramos diferenças, quando comparados com indivíduos que expressaram o outro transcrito. Conclusão: Concluímos que os transcritos do gene BCR-ABL não têm influência sobre os parâmetros hematológicos de pacientes com LMC nesse estudo.
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